Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5099713 | 0.97 | NPC1 (0.52) | NPC1ALOX5CYP3A4SMN1; SMN2PTPN2 | |
| SCHEMBL4657758 | 0.91 | NPC1 (0.48) | NPC1ALOX5CYP3A4SMN1; SMN2PTPN2 | |
| SCHEMBL5102101 | 0.90 | NPC1 (0.53) | NPC1ALOX5CYP3A4SMN1; SMN2PTPN2 | |
| SCHEMBL5108117 | 0.90 | GAA (0.53) | NPC1SMN1; SMN2GAA | |
| SCHEMBL5101716 | 0.90 | NPC1 (0.47) | NPC1ALOX5CYP3A4SMN1; SMN2PTPN2 | |
| SCHEMBL5098512 | 0.90 | CYP3A4 (0.57) | NPC1ALOX5CYP3A4SMN1; SMN2PTPN2 | |
| SCHEMBL2530050 | 0.89 | NPC1 (0.46) | NPC1ALOX5CYP3A4SMN1; SMN2PTPN2 | |
| SCHEMBL5095212 | 0.87 | NPC1 (0.48) | NPC1ALOX5SMN1; SMN2GAA | |
| SCHEMBL5095192 | 0.86 | NPC1 (0.44) | NPC1ALOX5CYP3A4 | |
| SCHEMBL5102097 | 0.86 | NPC1 (0.47) | NPC1ALOX5CYP3A4SMN1; SMN2PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130190504-A1 | Functionalized Polymers Using Protected Thiols | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2013-07-25 | — | — | US | disclosed |
| US-20130190504-A1 | Functionalized Polymers Using Protected Thiols | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2013-07-25 | — | — | US | disclosed |
| US-8283438-B2 | Functionalized polymers using protected thiols | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2012-10-09 | — | — | US | disclosed |
| US-8283438-B2 | Functionalized polymers using protected thiols | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2012-10-09 | — | — | US | disclosed |
| US-20110077407-A1 | Functionalized Polymers Using Protected Thiols | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2011-03-31 | — | — | US | disclosed |
| US-20110077407-A1 | Functionalized Polymers Using Protected Thiols | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2011-03-31 | — | — | US | disclosed |
| US-7847019-B2 | Functionalized polymers using protected thiols | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2010-12-07 | — | — | US | disclosed |
| US-7847019-B2 | Functionalized polymers using protected thiols | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2010-12-07 | — | — | US | disclosed |
| US-20090176941-A1 | Functionalized Polymers Using Protected Thiols | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2009-07-09 | — | — | US | disclosed |
| US-20090176941-A1 | Functionalized Polymers Using Protected Thiols | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2009-07-09 | — | — | US | disclosed |
| WO-2009052148-A1 | FUNCTIONALIZED POLYMERS USING PROTECTED THIOLS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2009-04-23 | — | — | WO | disclosed |
| EP-1419126-B1 | FLUOROUS NUCLEOPHILIC SUBSTITUTION OF ALCOHOLS AND REAGENTS FOR USE THEREIN | UNIV PITTSBURGH (US) | 2006-11-02 | — | — | EP | disclosed |
| US-6806357-B1 | REACTING THE ALCOHOL AND A NUCLEOPHILE WITH AN AZODICARBOXYLATE AND A PHOSPHINE. AT LEAST ONE OF THE AZODICARBOXYLATE AND THE PHOSPHINE INCLUDES AT LEAST ONE FLUOROUS TAG | UNIVERSITY OF PITTSBURGH | 2004-10-19 | — | — | US | disclosed |
| EP-1419126-A1 | FLUOROUS NUCLEOPHILIC SUBSTITUTION OF ALCOHOLS AND REAGENTS FOR USE THEREIN | UNIVERSITY OF PITTSBURGH (US) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003016246-A1 | FLUOROUS NUCLEOPHILIC SUBSTITUTION OF ALCOHOLS AND REAGENTS FOR USE THEREIN | UNIVERSITY OF PITTSBURGH (US) | 2003-02-27 | — | — | WO | disclosed |
| US-5830976-A | POLYAMIC ACID FROM BIPHENYLTETRACARBOXYLIC ACID AND (CYCLOHEXYLPHENOXY)ALKYL 3,5-DIAMINOBENZOATE, LIQUID CRYSTALS | CHISSO CORPORATION (JP) | 1998-11-03 | — | — | US | disclosed |
| US-5693379-A | LIQUID CRYSTAL ALIGNMENT FILM | CHISSO CORPORATION (JP) | 1997-12-02 | — | — | US | disclosed |
| US-5043152-A | Radiography | GUERBET S.A. (FR) | 1991-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077407-A1 | Functionalized Polymers Using Protected Thiols | TST, GNE, MGMT | NPC1 4431/4885ALOX5 171/4885CYP3A4 1698/4885 |
| US-20130190504-A1 | Functionalized Polymers Using Protected Thiols | TST, GNE, MGMT | NPC1 4431/4885ALOX5 171/4885CYP3A4 1698/4885 |
| US-20090176941-A1 | Functionalized Polymers Using Protected Thiols | TST, GNE, MGMT | NPC1 4431/4885ALOX5 171/4885CYP3A4 1698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.