Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.61 |
| ▸ | IDO1 | P14902 | 2/20 | 0.56 |
| ▸ | F10 | P00742 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 7/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3916599 | 0.98 | APP (0.63) | APPIDO1F10MAOBMAOA | |
| SCHEMBL30674750 | 0.98 | APP (0.63) | APPIDO1F10MAOBMAOA | |
| SCHEMBL5708184 | 0.95 | APP (0.59) | APPIDO1F10MAOBMAOA | |
| SCHEMBL314468 | 0.87 | APP (0.63) | APPMAOBMAOALCKCYP4F2 | |
| SCHEMBL1548932 | 0.84 | F10 (0.62) | APPF10MAOBMAOALCK | |
| SCHEMBL5708191 | 0.84 | APP (0.59) | APPMAOBMAOALCKCYP4F2 | |
| SCHEMBL32665169 | 0.83 | APP (0.59) | APPF10MAOBMAOALCK | |
| SCHEMBL9060683 | 0.82 | APP (0.64) | APPIDO1MAOBMAOA | |
| Formaldehyde SCHEMBL27783224 | 0.82 | NR4A2 (0.61) | APPMAOBMAOALCKCYP4F2 | |
| SCHEMBL15761340 | 0.80 | BCHE (0.70) | APPF10MAOBMAOALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706386-A1 | BICYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005066136-A1 | BICYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |