Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.40 |
| ▸ | PPARA | Q07869 | 6/20 | 0.38 |
| ▸ | PPARD | Q03181 | 5/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5708202 | 0.87 | PARP1 (0.40) | ADORA3PPARAPPARDPPARGPTGES | |
| SCHEMBL13791669 | 0.81 | ADORA3 (0.40) | ADORA3PPARAPPARDDGAT1SLC22A12 | |
| SCHEMBL3970539 | 0.80 | PARP1 (0.42) | ADORA3PPARAPPARD | |
| SCHEMBL3965691 | 0.77 | PPARA (0.42) | PPARAPPARDPPARGPTGES | |
| SCHEMBL3964883 | 0.77 | PPARD (0.42) | PPARAPPARDPPARG | |
| SCHEMBL3965838 | 0.74 | PPARA (0.52) | PPARAPPARDPPARG | |
| SCHEMBL3964173 | 0.73 | PPARA (0.51) | ADORA3PPARAPPARDPPARGADORA1 | |
| SCHEMBL3966215 | 0.73 | PPARD (0.41) | PPARAPPARD | |
| SCHEMBL3964282 | 0.72 | PPARD (0.41) | PPARAPPARDPPARGSLC22A12 | |
| SCHEMBL3968462 | 0.72 | PPARA (0.41) | ADORA3PPARAPPARDPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706386-A1 | BICYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-10-04 | — | — | EP | claimed |
| WO-2005066136-A1 | BICYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-07-21 | — | — | WO | claimed |