Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | BAX | Q07812 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5485556 | 0.98 | SMN1; SMN2 (0.56) | SMN1; SMN2RAD52BAXMAPTTP53 | |
| Trifluoroacetic Acid SCHEMBL7418749 | 0.86 | SMN1; SMN2 (0.43) | SMN1; SMN2RAD52BAXMAPTTP53 | |
| SCHEMBL11438133 | 0.86 | SMN1; SMN2 (0.60) | SMN1; SMN2RAD52BAXMAPTTP53 | |
| SCHEMBL151400 | 0.84 | SMN1; SMN2 (0.58) | SMN1; SMN2RAD52BAXMAPTTP53 | |
| SCHEMBL24319375 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2RAD52BAXMAPTTP53 | |
| SCHEMBL2800007 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2RAD52BAXMAPTTP53 | |
| SCHEMBL17934826 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2RAD52BAXMAPTTP53 | |
| SCHEMBL1361161 | 0.80 | MAPT (0.64) | SMN1; SMN2RAD52BAXMAPTTP53 | |
| SCHEMBL16908299 | 0.80 | MAPT (0.64) | SMN1; SMN2RAD52BAXMAPTTP53 | |
| SCHEMBL4400918 | 0.80 | MAPT (0.64) | SMN1; SMN2RAD52BAXMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601177-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | AstraZeneca AB (SE) | 2013-06-12 | — | — | EP | disclosed |
| CN-102757422-A | Derivatives of N-[(1H-pyrazol-1-yl)aryl]-1H-indole or 1H- indazole-3-carboxamide and their therapeutic uses as p2y12 antagonists | SANOFI SA | 2012-10-31 | — | — | CN | disclosed |
| WO-2012017251-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | WO | disclosed |