Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5709590 | 0.89 | REN (0.49) | REN | |
| SCHEMBL5709585 | 0.87 | REN (0.53) | REN | |
| SCHEMBL9730905 | 0.87 | REN (0.53) | REN | |
| SCHEMBL5709604 | 0.81 | REN (0.50) | REN | |
| SCHEMBL5709601 | 0.78 | REN (0.54) | REN | |
| SCHEMBL7373422 | 0.77 | REN (0.50) | REN | |
| SCHEMBL5709600 | 0.76 | REN (0.66) | REN | |
| SCHEMBL5709636 | 0.74 | CCR1 (0.64) | REN | |
| SCHEMBL5709565 | 0.73 | REN (0.62) | REN | |
| SCHEMBL9249864 | 0.73 | REN (0.62) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1712227-A1 | Amino diols useful in the treatment of Alzheimer's disease | Elan Pharmaceuticals, Inc. (US) | 2006-10-18 | — | — | EP | claimed |
| US-20050080141-A1 | Amino diols useful in the treatment of alzheimer's disease | SCHOSTAREZ HEINRICH J (US) | 2005-04-14 | — | — | US | claimed |
| EP-1712227-A1 | Amino diols useful in the treatment of Alzheimer's disease | Elan Pharmaceuticals, Inc. (US) | 2006-10-18 | — | — | EP | disclosed |
| US-20050080141-A1 | Amino diols useful in the treatment of alzheimer's disease | SCHOSTAREZ HEINRICH J (US) | 2005-04-14 | — | — | US | disclosed |
| EP-0431520-B1 | Heterocyclic acyl aminodiol beta-amino acid derivatives | SEARLE & CO (US) | 1995-02-08 | — | — | EP | disclosed |
| US-5283250-A | Renin inhibitor;hypotensive agent | G. D. SEARLE & CO. (US) | 1994-02-01 | — | — | US | disclosed |
| US-5231111-A | Imidazolyl/imidazolylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives | G. D. SEARLE & CO. (US) | 1993-07-27 | — | — | US | disclosed |
| US-5223532-A | Chromonyl/chromonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino derivatives | G. D. SEARLE & CO. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5223514-A | Renin inhibiros, hypotensive agents | G. D. SEARLE & CO. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5223534-A | Renin inhibitors, hypotensive agents | G. D. SEARLE & CO. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5217988-A | Renin inhibitor, hypotensive agent | G. D. SEARLE & CO. (US) | 1993-06-08 | — | — | US | disclosed |
| US-5217991-A | Renin inhibitors for treating hypertension | G. D. SEARLE & CO. (US) | 1993-06-08 | — | — | US | disclosed |
| US-5217989-A | Benothiophenyl/benzothiophenylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives | G. D. SEARLE & CO. (US) | 1993-06-08 | — | — | US | disclosed |
| US-5215996-A | Renin inhibitors; hypotensive agents | G. D. SEARLE & CO. (US) | 1993-06-01 | — | — | US | disclosed |
| US-5216013-A | Aralkyl-N-terminal cycloalkoxy-C terminal amino hydroxy β-amino acid derivatives | G. D. SEARLE & CO. (US) | 1993-06-01 | — | — | US | disclosed |
| US-5212174-A | Renin inhibitors for hypotensive agents | G. D. SEARLE & CO. (US) | 1993-05-18 | — | — | US | disclosed |
| US-5180725-A | Renin inhibitors | G. D. SEARLE & CO. (US) | 1993-01-19 | — | — | US | disclosed |
| US-5180744-A | Renin inhibitors; hypotensive agents | G. D. SEARLE & CO. (US) | 1993-01-19 | — | — | US | disclosed |
| US-5175170-A | Renin inhibitors, hypotensive agents | G. D. SEARLE & CO. (US) | 1992-12-29 | — | — | US | disclosed |
| US-5175181-A | Renin inhibitors, hypotensive agents | G. D. SEARLE & CO. (US) | 1992-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080141-A1 | Amino diols useful in the treatment of alzheimer's disease | BACE1, BACE2, APP | REN 2199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.