Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 19/20 | 0.41 |
| ▸ | MPEG1 | Q2M385 | 7/20 | 0.41 |
| ▸ | XIAP | P98170 | 2/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL571964 | 1.00 | ALDH1A1 (0.54) | ALDH1A1MAPTTDP1THRBALOX5 | |
| SCHEMBL571993 | 1.00 | ALDH1A1 (0.54) | ALDH1A1MAPTTDP1THRBALOX5 | |
| SCHEMBL571482 | 1.00 | ALDH1A1 (0.54) | ALDH1A1MAPTTDP1THRBALOX5 | |
| SCHEMBL571379 | 1.00 | ALDH1A1 (0.54) | ALDH1A1MAPTTDP1THRBALOX5 | |
| SCHEMBL571352 | 1.00 | ALDH1A1 (0.54) | ALDH1A1MAPTTDP1THRBALOX5 | |
| SCHEMBL571268 | 0.98 | ALDH1A1 (0.51) | ALDH1A1MAPTTDP1THRBALOX5 | |
| SCHEMBL570963 | 0.93 | MAPT (0.45) | ALDH1A1MAPTTDP1THRBALOX5 | |
| SCHEMBL571381 | 0.85 | NQO1 (0.38) | ALDH1A1MAPTTDP1THRBKDM4E | |
| SCHEMBL571989 | 0.84 | MAPT (0.60) | ALDH1A1MAPTTDP1THRBALOX5 | |
| SCHEMBL571069 | 0.84 | MAPT (0.60) | ALDH1A1MAPTTDP1THRBALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015183985-A2 | THERAPEUTIC COMPOSITIONS INCLUDING NAPHTHOQUINONES AND USES THEREOF | STEALTH PEPTIDES INTERNATIONAL, INC. (MC) | 2015-12-03 | — | — | WO | disclosed |
| EP-2600857-A2 | TREATMENT OF MITOCHONDRIAL DISEASES WITH NAPHTHOQUINONES | Edison Pharmaceuticals, Inc. (US) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012019029-A2 | TREATMENT OF MITOCHONDRIAL DISEASES WITH NAPHTHOQUINONES | EDISON PHARMACEUTICALS, INC. (US) | 2012-02-09 | — | — | WO | disclosed |