Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382780 | 0.81 | USP2 (0.50) | ALDH1A1SMN1; SMN2RECQLHRH3MAPT | |
| SCHEMBL4933010 | 0.80 | ALDH1A1 (0.56) | ALDH1A1POLBHTTSMN1; SMN2GAA | |
| SCHEMBL1684895 | 0.78 | — | — | |
| SCHEMBL10985089 | 0.78 | ALDH1A1 (0.72) | ALDH1A1POLBHTTSMN1; SMN2GAA | |
| SCHEMBL23561209 | 0.77 | ALDH1A1 (0.53) | ALDH1A1POLBHTTSMN1; SMN2GAA | |
| SCHEMBL6600585 | 0.77 | HRH3 (0.47) | HRH3KMT2AMEN1LMNA | |
| SCHEMBL2175867 | 0.77 | HRH3 (0.47) | ALDH1A1HTTHRH3MAPTKMT2A | |
| SCHEMBL12156720 | 0.77 | ALDH1A1 (0.56) | ALDH1A1POLBHTTSMN1; SMN2GAA | |
| SCHEMBL12312802 | 0.75 | ALDH1A1 (0.50) | ALDH1A1POLBHTTSMN1; SMN2GAA | |
| SCHEMBL926164 | 0.74 | TSHR (0.55) | ALDH1A1POLBHTTSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716130-A1 | ACETYLINIC PIPERAZINE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| US-20060235024-A1 | Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB | 2006-10-19 | — | — | US | disclosed |
| WO-2005080363-A1 | ACETYLINIC PIPERAZINE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235024-A1 | Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists | GRM1, GRIN1, GRM5 | ALDH1A1 788/4885POLB 3428/4885HTT 699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.