Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70367 | 0.90 | CES1 (0.56) | POLBNPSR1LMNAMAPTSMN1; SMN2 | |
| Hydrogen Sulfide SCHEMBL28313848 | 0.88 | TDP1 (0.54) | POLBNPSR1LMNAMAPTSMN1; SMN2 | |
| Acetoacetic Acid SCHEMBL27781228 | 0.84 | KMT2A (0.47) | POLBNPSR1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL5865907 | 0.81 | KMT2A (0.46) | POLBNPSR1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL396689 | 0.80 | PTPN1 (0.48) | POLBNPSR1MAPTSMN1; SMN2HPGD | |
| SCHEMBL27839718 | 0.79 | SMN1; SMN2 (0.58) | LMNAMAPTSMN1; SMN2HPGDKDM4E | |
| Acetophenone SCHEMBL28740713 | 0.78 | CES1 (0.58) | POLBLMNAMAPTSMN1; SMN2HPGD | |
| Acetophenone SCHEMBL27776436 | 0.77 | MAPT (0.65) | POLBLMNAMAPTSMN1; SMN2HPGD | |
| Acetophenone SCHEMBL30537000 | 0.77 | — | — | |
| Acetophenone SCHEMBL1450855 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601183-A1 | COUMARIN-CHALCONES AS ANTICANCER AGENTS | Council Of Scientific & Industrial Research (IN) | 2013-06-12 | — | — | EP | claimed |
| WO-2012017454-A1 | COUMARIN-CHALCONES AS ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-02-09 | — | — | WO | claimed |