Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 15/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL571575 | 0.95 | MAPT (0.58) | MAPTTDP1ALDH1A1THRBALOX5 | |
| SCHEMBL571593 | 0.94 | MAPT (0.60) | MAPTTDP1ALDH1A1THRBALOX5 | |
| SCHEMBL571008 | 0.94 | MAPT (0.60) | MAPTTDP1ALDH1A1THRBALOX5 | |
| SCHEMBL571500 | 0.94 | MAPT (0.60) | MAPTTDP1ALDH1A1THRBALOX5 | |
| SCHEMBL571989 | 0.94 | MAPT (0.60) | MAPTTDP1ALDH1A1THRBALOX5 | |
| SCHEMBL571069 | 0.94 | MAPT (0.60) | MAPTTDP1ALDH1A1THRBALOX5 | |
| SCHEMBL571947 | 0.90 | MAPT (0.42) | MAPTTDP1ALDH1A1THRBPDE3A | |
| SCHEMBL571247 | 0.83 | MALT1 (0.41) | ALDH1A1PDE3ACYP3A4MAOAMALT1 | |
| SCHEMBL570963 | 0.83 | MAPT (0.45) | MAPTTDP1ALDH1A1THRBALOX5 | |
| SCHEMBL571419 | 0.79 | IDO1 (0.59) | ALDH1A1ALOX5PDE3AMAOAMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015183985-A2 | THERAPEUTIC COMPOSITIONS INCLUDING NAPHTHOQUINONES AND USES THEREOF | STEALTH PEPTIDES INTERNATIONAL, INC. (MC) | 2015-12-03 | — | — | WO | disclosed |
| EP-2600857-A2 | TREATMENT OF MITOCHONDRIAL DISEASES WITH NAPHTHOQUINONES | Edison Pharmaceuticals, Inc. (US) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012019029-A2 | TREATMENT OF MITOCHONDRIAL DISEASES WITH NAPHTHOQUINONES | EDISON PHARMACEUTICALS, INC. (US) | 2012-02-09 | — | — | WO | disclosed |