Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | USP8 | P40818 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL571947 | 0.86 | MAPT (0.42) | MALT1CA1CA2CA7CA9 | |
| SCHEMBL571095 | 0.83 | MAPT (0.51) | MALT1PDE3BPDE3AALDH1A1CYP3A4 | |
| SCHEMBL571575 | 0.82 | MAPT (0.58) | PDE3AALDH1A1CYP3A4MAOA | |
| SCHEMBL571989 | 0.80 | MAPT (0.60) | PDE3AALDH1A1CYP3A4MAOA | |
| SCHEMBL571500 | 0.80 | MAPT (0.60) | PDE3AALDH1A1CYP3A4MAOA | |
| SCHEMBL571008 | 0.80 | MAPT (0.60) | PDE3AALDH1A1CYP3A4MAOA | |
| SCHEMBL571593 | 0.80 | MAPT (0.60) | PDE3AALDH1A1CYP3A4MAOA | |
| SCHEMBL571069 | 0.80 | MAPT (0.60) | PDE3AALDH1A1CYP3A4MAOA | |
| SCHEMBL571497 | 0.80 | NQO1 (0.43) | PDE3ACDC25ACDC25BKDM4EL3MBTL1 | |
| SCHEMBL571419 | 0.78 | IDO1 (0.59) | MALT1CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015183985-A2 | THERAPEUTIC COMPOSITIONS INCLUDING NAPHTHOQUINONES AND USES THEREOF | STEALTH PEPTIDES INTERNATIONAL, INC. (MC) | 2015-12-03 | — | — | WO | disclosed |
| EP-2600857-A2 | TREATMENT OF MITOCHONDRIAL DISEASES WITH NAPHTHOQUINONES | Edison Pharmaceuticals, Inc. (US) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012019029-A2 | TREATMENT OF MITOCHONDRIAL DISEASES WITH NAPHTHOQUINONES | EDISON PHARMACEUTICALS, INC. (US) | 2012-02-09 | — | — | WO | disclosed |