Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.53 |
| ▸ | KDR | P35968 | 19/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | FPR1 | P21462 | 1/20 | 0.48 |
| ▸ | FPR3 | P25089 | 1/20 | 0.48 |
| ▸ | GPR183 | P32249 | 1/20 | 0.48 |
| ▸ | SMO | Q99835 | 1/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4335688 | 1.00 | MET (0.53) | METKDRBRAFAURKAFPR1 | |
| SCHEMBL4325843 | 1.00 | MET (0.53) | METKDRBRAFAURKAFPR1 | |
| SCHEMBL4330439 | 0.96 | MET (0.54) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL4330023 | 0.93 | KDR (0.54) | METKDRBRAF | |
| SCHEMBL4330365 | 0.93 | KDR (0.54) | METKDRBRAF | |
| SCHEMBL13861590 | 0.92 | MET (0.50) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL4324389 | 0.90 | MET (0.50) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL4340618 | 0.90 | MET (0.52) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL13861548 | 0.89 | MET (0.53) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL13861545 | 0.89 | MET (0.53) | METKDRAURKAFPR1FPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1719763-A1 | NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (2) | Eisai Co., Ltd. (JP) | 2006-11-08 | — | — | EP | disclosed |