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Sugi Predict / Compounds / SCHEMBL571152

SCHEMBL571152

SCHEMBL571152

CCN(CCOP(=O)(OC(C)(C)C)OC(C)(C)C)CC[C@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCC(C(O)c4cc(Cl)ccc4-c4ccccc4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F

nearest known ligand 0.82

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ BCL2L1 Q07817 20/20 0.82
▸ BCL2 P10415 19/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL554205 0.95 BCL2L1 (0.91) BCL2L1BCL2
SCHEMBL554206 0.95 BCL2L1 (0.91) BCL2L1BCL2
SCHEMBL554204 0.95 BCL2L1 (0.91) BCL2L1BCL2
SCHEMBL19491755 0.95 BCL2L1 (0.91) BCL2L1BCL2
SCHEMBL571440 0.95 BCL2L1 (0.82) BCL2L1BCL2
SCHEMBL10225728 0.93 BCL2L1 (0.90) BCL2L1BCL2
SCHEMBL554831 0.90 BCL2L1 (1.00) BCL2L1BCL2
SCHEMBL554048 0.90 BCL2L1 (1.00) BCL2L1BCL2
SCHEMBL553334 0.90 BCL2L1 (1.00) BCL2L1BCL2
SCHEMBL554047 0.90 BCL2L1 (1.00) BCL2L1BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2601177-A1 N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS AstraZeneca AB (SE) 2013-06-12 — — EP disclosed
WO-2012017251-A1 N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS ASTRAZENECA AB (SE) 2012-02-09 — — WO disclosed
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