Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503933 | 0.93 | MAPT (0.70) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL5712810 | 0.91 | MAPT (0.65) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL5506679 | 0.90 | KMT2A (0.64) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL6998940 | 0.90 | MEN1 (0.63) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL6992785 | 0.90 | MAPT (0.63) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL7001450 | 0.88 | KMT2A (0.61) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL6994209 | 0.87 | MAPT (0.60) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL19475110 | 0.87 | MAPT (0.72) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL7687520 | 0.78 | MEN1 (0.53) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL7681433 | 0.76 | MEN1 (0.51) | MEN1KMT2AMAPTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1671973-A2 | Allosteric adenosine receptor modulators | King Pharmaceuticals Research and Development, Inc. (US) | 2006-06-21 | — | — | EP | claimed |
| EP-1025106-B1 | ALLOSTERIC ADENOSINE RECEPTOR MODULATORS | KING PHARMACEUTICALS RES & DEV (US) | 2006-06-21 | — | — | EP | claimed |
| EP-1671973-A2 | Allosteric adenosine receptor modulators | King Pharmaceuticals Research and Development, Inc. (US) | 2006-06-21 | — | — | EP | disclosed |
| EP-1025106-B1 | ALLOSTERIC ADENOSINE RECEPTOR MODULATORS | KING PHARMACEUTICALS RES & DEV (US) | 2006-06-21 | — | — | EP | disclosed |
| US-6323214-B1 | CARDIOVASCULAR DISORDERS, NERVOUS SYSTEM DISORDERS AND ANALGESICS | MEDCO RESEARCH, INC | 2001-11-27 | — | — | US | disclosed |