Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | PER2 | O15055 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL301524 | 0.93 | — | — | |
| Ammonia Solution, Strong SCHEMBL530826 | 0.91 | — | — | |
| Piperazine SCHEMBL27495864 | 0.82 | MEN1 (0.34) | KMT2AMEN1SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL6869257 | 0.80 | — | — | |
| SCHEMBL19291821 | 0.78 | SMN1; SMN2 (0.47) | KMT2AMEN1SMN1; SMN2POLBALDH1A1 | |
| Methacrylic Acid SCHEMBL521992 | 0.77 | KMT2A (0.40) | KMT2AMEN1SMN1; SMN2POLBALDH1A1 | |
| Acrylic Acid SCHEMBL7945092 | 0.77 | KMT2A (0.38) | KMT2AMEN1SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL530148 | 0.76 | TDP1 (0.40) | KMT2AMEN1SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL492432 | 0.76 | — | — | |
| Piperazine SCHEMBL27828153 | 0.75 | KMT2A (0.33) | KMT2AMEN1RAB9AFAAHNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465930-B1 | SUPRAMOLECULAR POLYMERS | ARKEMA (FR) | 2006-05-03 | — | — | EP | disclosed |