Sugi Predict

Sugi Predict / Compounds / Acyclovir

Acyclovir

Acyclovir

SCHEMBL571377

Nc1nc2c(ncn2COCCO)c(=O)[nH]1.O=P(O)(O)F

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PNP P00491 7/20 0.86
▸ BLM P54132 2/20 0.86
▸ HBB P68871 2/20 0.86
▸ USP2 O75604 1/20 0.86
▸ TSHR P16473 1/20 0.86
▸ EDNRA P25101 1/20 0.86
▸ HTR2A P28223 1/20 0.86
▸ RECQL P46063 1/20 0.86
▸ HSD17B10 Q99714 1/20 0.86
▸ HPRT1 P00492 7/20 0.78
▸ POLG P54098 2/20 0.70
▸ MEN1 O00255 2/20 0.61
▸ KMT2A Q03164 2/20 0.61
▸ ALDH1A1 P00352 1/20 0.61
▸ LMNA P02545 1/20 0.61
▸ CYP3A4 P08684 1/20 0.61
▸ NFKB1 P19838 1/20 0.61
▸ VCP P55072 1/20 0.61
▸ SMN1; SMN2 Q16637 1/20 0.61
▸ HIF1A Q16665 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acyclovir SCHEMBL145614 0.95 PNP (0.91) PNPBLMHBBUSP2TSHR
Acyclovir SCHEMBL23440044 0.95 PNP (0.91) PNPBLMHBBUSP2TSHR
Acyclovir SCHEMBL145606 0.95 PNP (0.91) PNPBLMHBBUSP2TSHR
Acyclovir SCHEMBL543440 0.95 PNP (0.91) PNPBLMHBBUSP2TSHR
Acyclovir SCHEMBL11310318 0.94 PNP (0.88) PNPBLMHBBUSP2TSHR
Acyclovir SCHEMBL28326009 0.94 PNP (0.88) PNPBLMHBBUSP2TSHR
Acyclovir SCHEMBL11310314 0.94 PNP (0.88) PNPBLMHBBUSP2TSHR
Acyclovir SCHEMBL571378 0.93 PNP (0.83) PNPBLMHBBUSP2TSHR
Acyclovir SCHEMBL6917017 0.93 PNP (0.86) PNPBLMHBBUSP2TSHR
Acyclovir SCHEMBL3175 0.93 PNP (1.00) PNPBLMHBBUSP2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140234271-A1 COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS THE HOSPITAL FOR SICK CHILDREN (CA) 2014-08-21 — — US disclosed
US-8748177-B2 Compositions for proliferation of cells and related methods THE HOSPITAL FOR SICK CHILDREN (CA) 2014-06-10 — — US disclosed
EP-2598150-A2 COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS The Hospital For Sick Children (CA) 2013-06-05 — — EP disclosed
WO-2012018643-A2 COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS THE HOSPITAL FOR SICK CHILDREN (CA) 2012-02-09 — — WO disclosed
US-20110301105-A1 COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS THE HOSPITAL FOR SICK CHILDREN (CA) 2011-12-08 — — US disclosed
WO-2010039679-A1 COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS THE HOSPITAL FOR SICK CHILDREN (CA) 2010-04-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140234271-A1 COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS MKI67, KRT18, PROX1 PNP 3880/4885BLM 2148/4885HBB 4494/4885
US-20110301105-A1 COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS MKI67, KRT18, PROX1 PNP 3880/4885BLM 2148/4885HBB 4494/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.