Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5714603 | 0.84 | ESR1 (0.33) | ESR1 | |
| SCHEMBL5714165 | 0.79 | ESR1 (0.30) | ESR1 | |
| SCHEMBL5714451 | 0.78 | NOTUM (0.37) | — | |
| SCHEMBL5713719 | 0.69 | ESR1 (0.34) | ESR1 | |
| SCHEMBL5713659 | 0.68 | ESR1 (0.35) | ESR1 | |
| SCHEMBL5714134 | 0.67 | ESR1 (0.34) | ESR1 | |
| SCHEMBL5713633 | 0.66 | ESR1 (0.33) | ESR1 | |
| SCHEMBL5713919 | 0.65 | ESR1 (0.31) | ESR1 | |
| SCHEMBL13547909 | 0.65 | ALDH1A1 (0.51) | — | |
| SCHEMBL3859373 | 0.63 | ESR1 (0.43) | ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1734961-A2 | METHODS OF TREATMENT OF AMYLOIDOSIS USING BI-CYCLIC ASPARTYL PROTEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2006-12-27 | — | — | EP | claimed |
| WO-2005087714-A2 | METHODS OF TREATMENT OF AMYLOIDOSIS USING BI-CYCLIC ASPARTYL PROTEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2005-09-22 | — | — | WO | claimed |