Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717200 | 0.83 | EPHX2 (0.46) | ALDH1A1LMNATRPV4EPHX2HCRTR1 | |
| SCHEMBL5716994 | 0.83 | HCRTR1 (0.46) | ALDH1A1GAATRPV4HCRTR1HCRTR2 | |
| SCHEMBL5717033 | 0.83 | ALDH1A1 (0.49) | ALDH1A1GAALMNATRPV4EPHX2 | |
| SCHEMBL5717229 | 0.80 | ALDH1A1 (0.43) | ALDH1A1GAATRPV4EPHX2BRD4 | |
| SCHEMBL5717214 | 0.80 | ALDH1A1 (0.43) | ALDH1A1GAATRPV4EPHX2BRD4 | |
| SCHEMBL5717206 | 0.80 | ALDH1A1 (0.43) | ALDH1A1GAATRPV4EPHX2BRD4 | |
| SCHEMBL15009887 | 0.68 | ALDH1A1 (0.77) | ALDH1A1GAALMNAEPHX2HSD11B1 | |
| SCHEMBL5169319 | 0.68 | KMT2A (0.48) | ALDH1A1GAALMNAMEN1KMT2A | |
| SCHEMBL28254937 | 0.67 | ALDH1A1 (0.74) | ALDH1A1GAALMNAEPHX2MEN1 | |
| SCHEMBL21324703 | 0.66 | HCRTR1 (0.48) | ALDH1A1GAAHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664010-A1 | SULFONAMIDES ANTAGONISING N-TYPE CALCIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005068448-A1 | SULFONAMIDES ANTAGONISING N-TYPE CALCIUM CHANNELS | IONIX PHARMACEUTICALS LIMITED (GB) | 2005-07-28 | — | — | WO | disclosed |