Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 9/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717025 | 0.88 | EPHX2 (0.44) | HCRTR1HCRTR2ALDH1A1MEN1TSHR | |
| SCHEMBL5716994 | 0.83 | HCRTR1 (0.46) | HCRTR1HCRTR2ALDH1A1MEN1TSHR | |
| SCHEMBL5717206 | 0.83 | ALDH1A1 (0.43) | HCRTR1HCRTR2ALDH1A1TRPV4 | |
| SCHEMBL5717229 | 0.83 | ALDH1A1 (0.43) | HCRTR1HCRTR2ALDH1A1TRPV4 | |
| SCHEMBL11888834 | 0.73 | MEN1 (0.50) | HCRTR1HCRTR2ALDH1A1MEN1TSHR | |
| SCHEMBL5717200 | 0.71 | EPHX2 (0.46) | HCRTR1HCRTR2ALDH1A1MEN1TSHR | |
| SCHEMBL5717180 | 0.70 | ITGB1 (0.38) | ALDH1A1L3MBTL1 | |
| SCHEMBL5717014 | 0.70 | ITGB1 (0.36) | ALDH1A1MEN1KMT2A | |
| SCHEMBL5717024 | 0.70 | HCRTR1 (0.64) | HCRTR1HCRTR2ALDH1A1MEN1TSHR | |
| SCHEMBL5717057 | 0.69 | HCRTR1 (0.60) | HCRTR1HCRTR2ALDH1A1MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664010-A1 | SULFONAMIDES ANTAGONISING N-TYPE CALCIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005068448-A1 | SULFONAMIDES ANTAGONISING N-TYPE CALCIUM CHANNELS | IONIX PHARMACEUTICALS LIMITED (GB) | 2005-07-28 | — | — | WO | disclosed |