Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5101900 | 0.91 | ALDH1A1 (0.43) | KDM4EALDH1A1SMN1; SMN2POLBHDAC6 | |
| SCHEMBL5102439 | 0.80 | MEN1 (0.51) | KDM4EALDH1A1SMN1; SMN2HDAC6HDAC1 | |
| SCHEMBL5115361 | 0.79 | MAPT (0.43) | L3MBTL1KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4499753 | 0.77 | ALDH1A1 (0.45) | KDM4EALDH1A1SMN1; SMN2POLBMEN1 | |
| SCHEMBL5102600 | 0.76 | HDAC6 (0.37) | KDM4EHDAC6HDAC1KMT2AGAA | |
| SCHEMBL5139069 | 0.75 | MAPT (0.42) | L3MBTL1KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4499121 | 0.74 | CUL4A (0.49) | KDM4EALDH1A1HDAC6HDAC1MEN1 | |
| SCHEMBL4500138 | 0.72 | KDM4E (0.46) | L3MBTL1KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5101860 | 0.72 | ALDH1A1 (0.42) | L3MBTL1KDM4EALDH1A1SMN1; SMN2HDAC6 | |
| SCHEMBL5114538 | 0.71 | TACR1 (0.40) | POLBHDAC6HDAC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1668009-A1 | HCV INHIBITORS AND METHODS OF USING THEM | Rigel Pharmaceuticals, Inc. (US) | 2006-06-14 | — | — | EP | claimed |
| WO-2005030774-A1 | HCV INHIBITORS AND METHODS OF USING THEM | RIGEL PHARMACEUTICALS, INC. (US) | 2005-04-07 | — | — | WO | claimed |