Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717819 | 0.88 | SIRT2 (0.65) | TSHRSIRT2HDAC2HDAC8HDAC1 | |
| SCHEMBL2211704 | 0.85 | HDAC1 (0.69) | TSHRHDAC2HDAC8HDAC1LMNA | |
| SCHEMBL6325165 | 0.82 | TSHR (0.76) | TSHRLMNAATMMITFTP53 | |
| SCHEMBL27930167 | 0.82 | SIRT2 (0.60) | TSHRSIRT2HDAC2HDAC8HDAC1 | |
| SCHEMBL5330405 | 0.82 | ALDH1A1 (0.83) | TSHRHDAC2HDAC8HDAC1LMNA | |
| SCHEMBL162090 | 0.81 | SIRT2 (0.69) | SIRT2HDAC2HDAC8HDAC1LMNA | |
| SCHEMBL6328232 | 0.81 | TSHR (0.74) | TSHRSIRT2HDAC2HDAC8HDAC1 | |
| SCHEMBL6332416 | 0.81 | TSHR (0.74) | TSHRSIRT2HDAC2HDAC8HDAC1 | |
| SCHEMBL1684613 | 0.81 | TSHR (0.74) | TSHRHDAC2HDAC8HDAC1LMNA | |
| SCHEMBL5717662 | 0.81 | TSHR (1.00) | TSHRSIRT2HDAC2HDAC8HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363925-B1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LTD (GB) | 2006-11-15 | — | — | EP | disclosed |
| CN-1492874-A | Macrolide antibiotics | — | 2004-04-28 | — | — | CN | disclosed |