Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 7/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29682662 | 1.00 | MDM4 (0.51) | MDM4TP53HDAC1HDAC2MDM2 | |
| SCHEMBL29400706 | 0.89 | MDM4 (0.54) | MDM4TP53HDAC1HDAC2MDM2 | |
| SCHEMBL29589719 | 0.89 | MDM4 (0.54) | MDM4TP53HDAC1HDAC2MDM2 | |
| SCHEMBL5717688 | 0.89 | MDM4 (0.54) | MDM4TP53HDAC1HDAC2MDM2 | |
| SCHEMBL27582559 | 0.89 | MDM4 (0.54) | MDM4TP53HDAC1HDAC2MDM2 | |
| SCHEMBL30234099 | 0.89 | MDM4 (0.54) | MDM4TP53HDAC1HDAC2MDM2 | |
| SCHEMBL18468298 | 0.87 | ITGB3 (0.48) | — | |
| SCHEMBL29401362 | 0.85 | MDM4 (0.51) | MDM4TP53HDAC1HDAC2MDM2 | |
| SCHEMBL3728174 | 0.82 | MDM4 (0.56) | MDM4TP53MDM2CASP3 | |
| SCHEMBL1486207 | 0.82 | MDM4 (0.56) | MDM4TP53MDM2SLC17A5CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363925-B1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LTD (GB) | 2006-11-15 | — | — | EP | disclosed |