Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.32 |
| ▸ | AKR1C4 | P17516 | 3/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717812 | 1.00 | DDR1 (0.32) | DDR1AKR1C3AKR1C4AKR1C2PDE4A | |
| SCHEMBL5717904 | 0.97 | DDR1 (0.31) | DDR1AKR1C3AKR1C4 | |
| SCHEMBL5717909 | 0.97 | DDR1 (0.31) | DDR1AKR1C3AKR1C4 | |
| SCHEMBL5717814 | 0.89 | DDR1 (0.33) | DDR1MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL4361512 | 0.87 | PDE4A (0.37) | DDR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4345980 | 0.86 | KDM4E (0.36) | RAB9A | |
| SCHEMBL4345974 | 0.86 | KDM4E (0.36) | RAB9A | |
| SCHEMBL5717776 | 0.84 | PDE4A (0.36) | DDR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4348405 | 0.83 | SMN1; SMN2 (0.39) | DDR1MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL4348547 | 0.82 | KDM4E (0.39) | AKR1C3AKR1C4MAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |