Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 4/20 | 0.37 |
| ▸ | THRA | P10827 | 3/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4922926 | 0.90 | SMN1; SMN2 (0.38) | SMN1; SMN2MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL4353638 | 0.88 | GPR139 (0.39) | SMN1; SMN2MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL4355678 | 0.87 | THRA (0.43) | SMN1; SMN2MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL5110782 | 0.86 | CA1 (0.37) | SMN1; SMN2MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL5717812 | 0.83 | DDR1 (0.32) | SMN1; SMN2MAPTRAB9AL3MBTL1DDR1 | |
| SCHEMBL5717815 | 0.83 | DDR1 (0.32) | SMN1; SMN2MAPTRAB9AL3MBTL1DDR1 | |
| SCHEMBL4361512 | 0.82 | PDE4A (0.37) | SMN1; SMN2MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL4927472 | 0.82 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL4922427 | 0.81 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL5717904 | 0.81 | DDR1 (0.31) | DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | disclosed |
| US-20080221210-A1 | Thyroid Receptor Agonists | KARO BIO AB (SE) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221210-A1 | Thyroid Receptor Agonists | TSHR, TRHR, THRA | SMN1; SMN2 4282/4885MAPT 4142/4885RAB9A 986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.