Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 8/20 | 0.57 |
| ▸ | PDE1A | P54750 | 4/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | SCD | O00767 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717687 | 0.89 | SCD (0.63) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL5717620 | 0.82 | KDM4E (0.74) | CSNK2A1PDE5APDE1APDE1BPDE1C | |
| SCHEMBL419064 | 0.81 | ALDH1A1 (0.58) | ALDH1A1MEN1MAPTPKMKMT2A | |
| SCHEMBL13341995 | 0.80 | F2 (0.59) | CSNK2A1PDE5AALDH1A1MEN1MAPT | |
| SCHEMBL27928219 | 0.79 | PDE5A (0.53) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL5717678 | 0.78 | GCK (0.65) | CSNK2A1PDE5APDE1APDE1BPDE1C | |
| SCHEMBL13342001 | 0.78 | KMT2A (0.70) | CSNK2A1PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3594519 | 0.76 | ALDH1A1 (0.59) | ALDH1A1MEN1MAPTPKMKMT2A | |
| SCHEMBL3610516 | 0.76 | ALDH1A1 (0.59) | ALDH1A1MEN1MAPTPKMKMT2A | |
| SCHEMBL2753300 | 0.76 | MEN1 (0.52) | PDE5APDE1APDE1BPDE1CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363925-B1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LTD (GB) | 2006-11-15 | — | — | EP | disclosed |
| US-20060211636-A1 | Macrolide Antibiotics | ALIHODZIC SULEJMAN | 2006-09-21 | — | — | US | disclosed |
| US-20050215495-A1 | Macrolide antibiotics | ALIHODZIC SULEJMAN | 2005-09-29 | — | — | US | disclosed |
| US-20040077557-A1 | Macrolide antibiotics | GLAXO GROUP LIMITED (GB) | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215495-A1 | Macrolide antibiotics | IL1R1, MRPL12, RPS21 | CSNK2A1 2045/4885PDE5A 3027/4885PDE1A 4808/4885 |
| US-20060211636-A1 | Macrolide Antibiotics | IL1R1, MRPL12, RPS21 | CSNK2A1 2045/4885PDE5A 3027/4885PDE1A 4808/4885 |
| US-20040077557-A1 | Macrolide antibiotics | MALT1, MRPL21, IL1R1 | CSNK2A1 2125/4885PDE5A 3428/4885PDE1A 4744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.