Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 12/20 | 0.48 |
| ▸ | THRB | P10828 | 12/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | HSPH1 | Q92598 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717855 | 0.92 | THRA (0.41) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4364107 | 0.88 | THRA (0.48) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4931455 | 0.85 | THRA (0.41) | THRATHRBPPARDPPARGMRGPRX4 | |
| SCHEMBL4923379 | 0.84 | SMN1; SMN2 (0.38) | THRATHRBMRGPRX4 | |
| SCHEMBL5718176 | 0.83 | THRA (0.39) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4348531 | 0.82 | THRA (0.58) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4934638 | 0.82 | THRA (0.60) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4364113 | 0.80 | THRA (0.40) | THRATHRBMRGPRX4 | |
| SCHEMBL4933436 | 0.79 | MRGPRX4 (0.40) | MRGPRX4 | |
| SCHEMBL4934248 | 0.78 | THRA (0.44) | THRATHRBMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |