Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 19/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5718036 | 0.88 | THRA (0.61) | THRATHRBFFAR1FFAR4AKR1B1 | |
| SCHEMBL4353468 | 0.86 | THRA (0.76) | THRATHRBFFAR1FFAR4 | |
| SCHEMBL5718107 | 0.86 | THRA (0.59) | THRATHRBFFAR1FFAR4AKR1B1 | |
| SCHEMBL5718371 | 0.85 | THRA (0.55) | THRATHRBFFAR1FFAR4AKR1B1 | |
| SCHEMBL5718079 | 0.82 | THRA (0.57) | THRATHRBFFAR1FFAR4AKR1B1 | |
| SCHEMBL5718671 | 0.81 | THRA (0.56) | THRATHRBFFAR1FFAR4AKR1B1 | |
| SCHEMBL5718678 | 0.81 | THRA (0.56) | THRATHRBFFAR1FFAR4AKR1B1 | |
| SCHEMBL5718382 | 0.80 | THRA (0.58) | THRATHRBFFAR1FFAR4AKR1B1 | |
| SCHEMBL5718174 | 0.80 | FFAR1 (0.54) | THRATHRBFFAR1FFAR4AKR1B1 | |
| SCHEMBL5718217 | 0.79 | THRA (0.53) | THRATHRBFFAR1FFAR4AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |