Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1715722 | 0.85 | TSHR (0.41) | NPC1RAB9AGPR6LRRK2PDE5A | |
| SCHEMBL12461145 | 0.77 | PDE5A (0.41) | PDE5APDCD1CD274USP2ALDH1A1 | |
| SCHEMBL1715615 | 0.76 | POLB (0.44) | NPC1RAB9AGPR6PDE5AALDH1A1 | |
| SCHEMBL1715115 | 0.75 | KDR (0.47) | PDE5A | |
| SCHEMBL1715528 | 0.73 | KIT (0.49) | NR3C2PDE5ARXFP1GLATSHR | |
| SCHEMBL12230044 | 0.72 | TSHR (0.41) | NPC1RAB9ANR3C2RXFP1ALDH1A1 | |
| SCHEMBL1714112 | 0.72 | TSHR (0.41) | NPC1RAB9APDE5APDE4APDE4B | |
| SCHEMBL5718667 | 0.71 | NR3C2 (0.40) | NPC1RAB9AGPR6HCRTR1HCRTR2 | |
| SCHEMBL5718526 | 0.71 | USP2 (0.35) | NR3C2PDE5AUSP2ALDH1A1LMNA | |
| SCHEMBL1715441 | 0.71 | KDM4C (0.48) | LRRK2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697312-A2 | HYDROXAMIC ACID ESTERS AND PHARMACEUTICAL USE THEREOF | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005054179-A2 | HYDROXAMIC ACID ESTERS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2005-06-16 | — | — | WO | disclosed |