Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Urethane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urethane SCHEMBL442854 | 0.94 | — | — | |
| Urethane SCHEMBL50516 | 0.87 | ALOX15 (0.83) | ALOX15ALDH1A1LMNAHSD17B10HCAR2 | |
| Urethane SCHEMBL11239486 | 0.87 | ALOX15 (0.83) | ALOX15ALDH1A1LMNAHSD17B10HCAR2 | |
| Urethane SCHEMBL7943960 | 0.87 | ALOX15 (0.83) | ALOX15ALDH1A1LMNAHSD17B10HCAR2 | |
| Urethane SCHEMBL2566577 | 0.85 | ALOX15 (0.54) | ALOX15ALDH1A1LMNAHSD17B10GLO1 | |
| Urethane SCHEMBL23827903 | 0.83 | ALOX15 (0.68) | ALOX15ALDH1A1LMNAHSD17B10HCAR2 | |
| Urethane SCHEMBL5604653 | 0.83 | ALOX15 (0.68) | ALOX15ALDH1A1LMNAHSD17B10HCAR2 | |
| Urethane SCHEMBL27446 | 0.83 | ALOX15 (0.68) | ALOX15ALDH1A1LMNAHSD17B10HCAR2 | |
| Urethane SCHEMBL7940552 | 0.83 | ALOX15 (0.68) | ALOX15ALDH1A1LMNAHSD17B10HCAR2 | |
| Urethane SCHEMBL8318196 | 0.83 | ALOX15 (0.68) | ALOX15ALDH1A1LMNAHSD17B10HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-63157315-A | — | — | None | — | — | JP | disclosed |
| EP-1697312-A2 | HYDROXAMIC ACID ESTERS AND PHARMACEUTICAL USE THEREOF | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005054179-A2 | HYDROXAMIC ACID ESTERS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2005-06-16 | — | — | WO | disclosed |
| EP-0717079-B1 | Injection molded article for photographic photosensitive material, molding method thereof and package using the same | FUJI PHOTO FILM CO LTD (JP) | 2002-07-24 | — | — | EP | disclosed |
| US-5827584-A | POLYMER BLEND WITH LIGHT SHIELD AND FIBERS, ANTIOXIDANT, AGING RESISTOR, RADIATION ABSORBER, FATTY ACID SALT, RADICAL SCAVENGER AND DOUBLE SALT COMPOUND | FUJI PHOTO FILM CO., LTD. (JP) | 1998-10-27 | — | — | US | disclosed |
| EP-0717079-A2 | Injection molded article for photographic photosensitive material, molding method thereof and package using the same | Fuji Photo Film Co., Ltd. (JP) | 1996-06-19 | — | — | EP | disclosed |
| JP-S63157315-A | MAGNETIC RECORDING MEDIUM | FUJI PHOTO FILM CO LTD | 1988-06-30 | — | — | JP | disclosed |