Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MASP2 | O00187 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ESRRA | P11474 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPD | P32754 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9282689 | 0.89 | MAPT (0.45) | MAPTTDP1LMNAPOLBCCR6 | |
| Ammonia Solution, Strong SCHEMBL5720368 | 0.88 | MAPT (0.45) | MAPTTDP1LMNAPOLBCCR6 | |
| Ammonia Solution, Strong SCHEMBL5720361 | 0.88 | MAPT (0.45) | MAPTTDP1LMNAPOLBCCR6 | |
| SCHEMBL8438235 | 0.84 | MAPT (0.46) | MAPTTDP1LMNAPOLBCCR6 | |
| Ammonia Solution, Strong SCHEMBL8433966 | 0.83 | MAPT (0.45) | MAPTTDP1LMNAPOLBCCR6 | |
| Ammonia Solution, Strong SCHEMBL8433967 | 0.83 | MAPT (0.45) | MAPTTDP1LMNAPOLBCCR6 | |
| Ammonia Solution, Strong SCHEMBL8433971 | 0.83 | MAPT (0.45) | MAPTTDP1LMNAPOLBCCR6 | |
| SCHEMBL8740797 | 0.80 | MAPT (0.56) | MAPTTDP1LMNAPOLBCCR6 | |
| SCHEMBL8435213 | 0.79 | SMN1; SMN2 (0.52) | MAPTTDP1LMNAPOLBHPGD | |
| SCHEMBL8077154 | 0.78 | MAPT (0.54) | MAPTTDP1LMNAPOLBCCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841910-A4 | INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2006-09-13 | — | — | EP | disclosed |
| EP-0841910-A1 | INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997004765-A1 | INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-13 | — | — | WO | disclosed |