Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | PPOX | P50336 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
| ▸ | HPD | P32754 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8077154 | 0.89 | MAPT (0.54) | MAPTTDP1LMNAMEN1KMT2A | |
| SCHEMBL8077157 | 0.88 | MAPT (0.48) | MAPTTDP1LMNAMEN1KMT2A | |
| SCHEMBL9120684 | 0.86 | MAPT (0.48) | MAPTTDP1LMNAMEN1KMT2A | |
| SCHEMBL8438235 | 0.83 | MAPT (0.46) | MAPTTDP1LMNAMEN1KMT2A | |
| SCHEMBL8077059 | 0.82 | ALDH1A1 (0.51) | MAPTLMNAMEN1KMT2APOLB | |
| Ammonia Solution, Strong SCHEMBL8433971 | 0.82 | MAPT (0.45) | MAPTTDP1LMNAMEN1KMT2A | |
| SCHEMBL9282689 | 0.82 | MAPT (0.45) | MAPTTDP1LMNAMEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL8433967 | 0.82 | MAPT (0.45) | MAPTTDP1LMNAMEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL8433966 | 0.82 | MAPT (0.45) | MAPTTDP1LMNAMEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL5720361 | 0.81 | MAPT (0.45) | MAPTTDP1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799198-A4 | — | — | 1997-10-15 | — | — | EP | disclosed |
| EP-0799198-A1 | ANTI-INFLAMMATORY COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-08 | — | — | EP | disclosed |
| WO-1995033461-A1 | ANTI-INFLAMMATORY COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-12-14 | — | — | WO | disclosed |
| WO-1995033460-A1 | ANTI-INFLAMMATORY COUMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-12-14 | — | — | WO | disclosed |