Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 13/20 | 0.49 |
| ▸ | CDK2 | P24941 | 13/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 13/20 | 0.49 |
| ▸ | AURKA | O14965 | 10/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.34 |
| ▸ | PIP5K1C | O60331 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5720832 | 0.78 | AURKA (0.40) | CCNA2CDK2CCNA1AURKAPKM | |
| SCHEMBL21995304 | 0.77 | CCNA2 (0.39) | CCNA2CDK2CCNA1AURKA | |
| SCHEMBL5720815 | 0.77 | BRD4 (0.55) | CCNA2CDK2CCNA1AURKAMAPK1 | |
| SCHEMBL5720818 | 0.73 | CDK2 (0.46) | CCNA2CDK2CCNA1AURKACCNE2 | |
| SCHEMBL5720897 | 0.73 | NPC1 (0.52) | CCNA2CDK2CCNA1AURKASMN1; SMN2 | |
| SCHEMBL5720863 | 0.73 | CCNA2 (0.46) | CCNA2CDK2CCNA1AURKACCNB2 | |
| SCHEMBL5720827 | 0.72 | CCNA2 (0.46) | CCNA2CDK2CCNA1AURKACCNB2 | |
| SCHEMBL5720844 | 0.71 | NR1H2 (0.40) | CCNA2CDK2CCNA1AURKASMN1; SMN2 | |
| SCHEMBL5720849 | 0.71 | BRD4 (0.46) | CCNA2CDK2CCNA1AURKASMN1; SMN2 | |
| SCHEMBL19297277 | 0.70 | RBP4 (0.39) | CCNA2CDK2CCNA1AURKACCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060135508-A1 | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-06-22 | — | — | US | disclosed |
| EP-1527074-A1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004013144-A1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2004-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135508-A1 | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K15, MAP3K5, MAP3K19 | CCNA2 915/4885CDK2 52/4885CCNA1 790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.