Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30090465 | 0.85 | NR1H2 (0.40) | NR1H2C5AR1USP2SMN1; SMN2DDB1 | |
| SCHEMBL3480008 | 0.84 | NR1H2 (0.40) | NR1H2C5AR1USP2SMN1; SMN2DDB1 | |
| SCHEMBL30707227 | 0.83 | NR1H2 (0.39) | NR1H2C5AR1USP2SMN1; SMN2DDB1 | |
| SCHEMBL29723403 | 0.82 | NR1H2 (0.38) | NR1H2C5AR1USP2SMN1; SMN2DDB1 | |
| SCHEMBL30707378 | 0.82 | NR1H2 (0.38) | NR1H2C5AR1USP2SMN1; SMN2DDB1 | |
| SCHEMBL29723289 | 0.81 | C5AR1 (0.38) | NR1H2C5AR1USP2SMN1; SMN2DDB1 | |
| SCHEMBL5720821 | 0.80 | CKS1B (0.42) | C5AR1DDB1CRBNMAPK1PARP1 | |
| SCHEMBL5720844 | 0.78 | NR1H2 (0.40) | NR1H2USP2SMN1; SMN2DDB1CRBN | |
| SCHEMBL6439338 | 0.78 | HTT (0.51) | C5AR1SMN1; SMN2 | |
| SCHEMBL28970100 | 0.77 | NR1H2 (0.37) | NR1H2USP2SMN1; SMN2DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621230-B | Nitrogen-containing heterocyclic compound, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2023-06-16 | — | — | CN | disclosed |
| CN-115806561-A | JAK3 selective inhibitors and uses thereof | 南京药石科技股份有限公司 | 2023-03-17 | — | — | CN | disclosed |
| CN-114621230-A | Nitrogen-containing heterocyclic compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-06-14 | — | — | CN | disclosed |
| US-10155775-B2 | Substituted amino six-membered saturated heteroalicycles as long-acting DPP-IV inhibitors | CENTAURUS BIOPHARMA CO., LTD. (CN) | 2018-12-18 | — | — | US | disclosed |
| US-20180111950-A1 | SUBSTITUTED AMINO SIX-MEMBERED SATURATED HETEROALICYCLES AS LONG-ACTING DPP-IV INHIBITORS | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-04-26 | — | — | US | disclosed |
| US-20180111950-A1 | SUBSTITUTED AMINO SIX-MEMBERED SATURATED HETEROALICYCLES AS LONG-ACTING DPP-IV INHIBITORS | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-04-26 | — | — | US | disclosed |
| US-20180111950-A1 | SUBSTITUTED AMINO SIX-MEMBERED SATURATED HETEROALICYCLES AS LONG-ACTING DPP-IV INHIBITORS | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-04-26 | — | — | US | disclosed |
| EP-3257857-A1 | SUBSTITUTED AMINO SIX-MEMBERED SATURATED HETEROCYCLIC FAT USED AS LONG-ACTING DPP-IV INHIBITOR | Centaurus BioPharma Co., Ltd. (CN) | 2017-12-20 | — | — | EP | disclosed |
| EP-3257857-A1 | SUBSTITUTED AMINO SIX-MEMBERED SATURATED HETEROCYCLIC FAT USED AS LONG-ACTING DPP-IV INHIBITOR | Centaurus BioPharma Co., Ltd. (CN) | 2017-12-20 | — | — | EP | disclosed |
| WO-2016127916-A1 | SUBSTITUTED AMINO SIX-MEMBERED SATURATED HETEROCYCLIC FAT USED AS LONG-ACTING DPP-IV INHIBITOR | 北京赛林泰医药技术有限公司 | 2016-08-18 | — | — | WO | disclosed |
| US-20060135508-A1 | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-06-22 | — | — | US | disclosed |
| EP-1527074-A1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004013144-A1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2004-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180111950-A1 | SUBSTITUTED AMINO SIX-MEMBERED SATURATED HETEROALICYCLES AS LONG-ACTING DPP-IV INHIBITORS | DPP4, DPP7, DPP9 | NR1H2 3612/4885C5AR1 3153/4885USP2 1692/4885 |
| US-20060135508-A1 | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K15, MAP3K5, MAP3K19 | NR1H2 4654/4885C5AR1 3538/4885USP2 2867/4885 |
| US-10155775-B2 | Substituted amino six-membered saturated heteroalicycles as long-acting DPP-IV inhibitors | DPP4, DPP7, DPP9 | NR1H2 3612/4885C5AR1 3153/4885USP2 1692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.