Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 7/20 | 0.79 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.79 |
| ▸ | CA12 | O43570 | 2/20 | 0.79 |
| ▸ | CA2 | P00918 | 2/20 | 0.79 |
| ▸ | CA4 | P22748 | 2/20 | 0.79 |
| ▸ | CA7 | P43166 | 2/20 | 0.79 |
| ▸ | ACHE | P22303 | 1/20 | 0.79 |
| ▸ | NQO2 | P16083 | 1/20 | 0.75 |
| ▸ | GAA | P10253 | 5/20 | 0.75 |
| ▸ | POLB | P06746 | 4/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.75 |
| ▸ | APEX1 | P27695 | 2/20 | 0.75 |
| ▸ | RECQL | P46063 | 2/20 | 0.75 |
| ▸ | XDH | P47989 | 2/20 | 0.75 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.70 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | ALPL | P05186 | 2/20 | 0.68 |
| ▸ | ALPI | P09923 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9993267 | 1.00 | P4HB (0.79) | P4HBAKR1B1CA12CA2CA4 | |
| SCHEMBL30456667 | 1.00 | P4HB (0.79) | P4HBAKR1B1CA12CA2CA4 | |
| SCHEMBL31720497 | 1.00 | P4HB (0.79) | P4HBAKR1B1CA12CA2CA4 | |
| SCHEMBL30217549 | 1.00 | P4HB (0.79) | P4HBAKR1B1CA12CA2CA4 | |
| SCHEMBL30637576 | 1.00 | P4HB (0.79) | P4HBAKR1B1CA12CA2CA4 | |
| SCHEMBL2164091 | 0.97 | P4HB (0.73) | P4HBAKR1B1CA12CA2CA4 | |
| SCHEMBL31236368 | 0.95 | P4HB (0.84) | P4HBAKR1B1CA12CA2CA4 | |
| SCHEMBL31236361 | 0.95 | P4HB (0.84) | P4HBAKR1B1CA12CA2CA4 | |
| SCHEMBL30106662 | 0.95 | P4HB (0.84) | P4HBAKR1B1CA12CA2CA4 | |
| SCHEMBL31236369 | 0.95 | P4HB (0.84) | P4HBAKR1B1CA12CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140234271-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2014-08-21 | — | — | US | disclosed |
| US-8748177-B2 | Compositions for proliferation of cells and related methods | THE HOSPITAL FOR SICK CHILDREN (CA) | 2014-06-10 | — | — | US | disclosed |
| EP-2598150-A2 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | The Hospital For Sick Children (CA) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012018643-A2 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2012-02-09 | — | — | WO | disclosed |
| US-20110301105-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2011-12-08 | — | — | US | disclosed |
| WO-2010039679-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140234271-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | MKI67, KRT18, PROX1 | P4HB 3209/4885AKR1B1 1043/4885CA12 1642/4885 |
| US-20110301105-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | MKI67, KRT18, PROX1 | P4HB 3209/4885AKR1B1 1043/4885CA12 1642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.