P4HB — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL24312	0.64	15/20
SCHEMBL24313	0.64	15/20
SCHEMBL172849	0.46	14/20
SCHEMBL327680	0.51	12/20
SCHEMBL127878	0.49	9/20
Balazipone (SCHEMBL636109)	0.48	9/20
SCHEMBL67236	0.49	8/20
Quercitrin (SCHEMBL117644)	1.00	7/20
Quercitrin (SCHEMBL147092)	1.00	7/20
Quercitrin (SCHEMBL147093)	1.00	7/20
SCHEMBL572182	0.79	7/20
SCHEMBL385988	0.72	7/20
SCHEMBL385989	0.72	7/20
SCHEMBL99552	0.53	7/20
SCHEMBL99553	0.53	7/20
SCHEMBL195319	0.45	7/20
Isoquercetin (SCHEMBL23249)	1.00	6/20
Isoquercetin (SCHEMBL24609)	1.00	6/20
Isoquercetin (SCHEMBL181306)	1.00	6/20
Nicotifloroside (SCHEMBL240355)	1.00	6/20

Clinical trials — most relevant to P4HB by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Androgen Ablation Therapy With or Without Chemotherapy in Treating Patients With Metastatic Prostate Cancer	PHASE3	COMPLETED
Glycerol-Phenylbutyrate Treatment in Children With MCT Mutation (Allan-Herndon- Dudley Syndrome)	PHASE2/PHASE3	UNKNOWN
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors	PHASE1	COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors	PHASE1	COMPLETED
Nebulised BromAc in Healthy Volunteers	PHASE1	COMPLETED
PBA Use for Treatment of ATF6-/- Patients	EARLY_PHASE1	SUSPENDED
Effects of Preoperative Oral Carbohydrate Loading on Maternal Thiol-disulfide Homeostasis	nan	COMPLETED
Thiol/Disulphide Homeostasis in Unexplained Infertility	nan	COMPLETED
Quantification of GADD34 Expression in RA	nan	COMPLETED
Modes of Delivery Impact Maternal Oxidative Stress Biomarkers and Dynamic Thiol Disulphide Homeostasis	nan	COMPLETED
Evaluation of Mitochondrial Enzyme Activity in Cesarean Section Patients	nan	UNKNOWN
Effect of Thiol-Disulfide Homeostasis and Ischemia-Modified Albumin Levels on IVF Results in Male Factor Infertility	nan	COMPLETED
Long Term Prediction of MASH-related HCC Risk by Proteomics	nan	NOT_YET_RECRUITING
The Effects of Dexmedetomidine on Thiol/Disulphide Homeostasis in Coronary Bypass Surgery	nan	UNKNOWN
Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse	nan	COMPLETED
Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection	nan	UNKNOWN
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD)	nan	COMPLETED
Fatty Acids Lipidome and Oxidative Stress in Liver Transplantation	nan	UNKNOWN
Proteomic Profiling to Reveal Novel Prognostic Markers for Neurological Outcome Following Resuscitation	nan	COMPLETED
Zinc and the Synthesis of Zinc Binding Proteins (Protocol B)	nan	COMPLETED
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Comparison of Oxidants and Antioxidants in Breastmilk Under Different Anesthesia Protocols	nan	COMPLETED
SEXI: Sciatic Expression and Identification of Differential Proteins in Traumatized Versus Nontraumatized Nerves	nan	UNKNOWN
Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery	nan	COMPLETED
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia	nan	RECRUITING
Integrated Proteomic HPLC-ESI-MS Analysis of Salivary Peptides of Preterm Newborns: a Pilot Study	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a P4HB binder may also engage these)

Protein	Name	Similarity
Q5R5B6	—	1.000	Q5R5B6 →
Q2HWU2	—	1.000	Q2HWU2 →
P05307	—	1.000	P05307 →
Q8R4U2	—	1.000	Q8R4U2 →
P04785	—	1.000	P04785 →
P09103	—	1.000	P09103 →
P09102	—	1.000	P09102 →
P21195	—	1.000	P21195 →
P54399	—	0.996	P54399 →
Q17770	—	0.996	Q17770 →
PDIA4	Protein disulfide-isomerase A4	0.995	landscape →
Q53LQ0	—	0.994	Q53LQ0 →
P38657	—	0.994	P38657 →
P08003	—	0.993	P08003 →
Q29RV1	—	0.993	Q29RV1 →
Q43116	—	0.992	Q43116 →
P29828	—	0.992	P29828 →
Q4VIT4	—	0.992	Q4VIT4 →
Q9XI01	—	0.992	Q9XI01 →
P11598	—	0.992	P11598 →
P80284	—	0.991	P80284 →
P38659	—	0.991	P38659 →
P27773	—	0.991	P27773 →
Q5RDG4	—	0.988	Q5RDG4 →
PDIA3	Protein disulfide-isomerase A3	0.988	landscape →
Q8JG64	—	0.988	Q8JG64 →
Q12730	—	0.987	Q12730 →
P52588	—	0.986	P52588 →
Q9SRG3	—	0.986	Q9SRG3 →
Q67IX6	—	0.986	Q67IX6 →