Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5525291 | 1.00 | TDP1 (0.41) | TDP1DRD4TP53MAPTHPGD | |
| SCHEMBL5526297 | 1.00 | TDP1 (0.41) | TDP1DRD4TP53MAPTHPGD | |
| SCHEMBL5523339 | 0.89 | DRD4 (0.41) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL14451442 | 0.89 | DRD4 (0.41) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL5722035 | 0.89 | DRD4 (0.41) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL5523335 | 0.89 | DRD4 (0.41) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL5525141 | 0.85 | TDP1 (0.60) | TDP1TP53MAPTHPGDTSHR | |
| SCHEMBL5522838 | 0.81 | NFE2L2 (0.41) | DRD2HTR2A | |
| SCHEMBL14451440 | 0.80 | DRD4 (0.41) | DRD4DRD2HTR2A | |
| SCHEMBL5519516 | 0.80 | DRD4 (0.41) | DRD4DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716100-A2 | THERAPEUTIC AMIDE DERIVATIVES | Pfizer, Inc. (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080317-A2 | THERAPEUTIC AMIDE DERIVATIVES | PFIZER JAPAN, INC. (JP) | 2005-09-01 | — | — | WO | disclosed |