Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 16/20 | 0.45 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966279 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1LMNAMAPTCNR2 | |
| SCHEMBL5722144 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1LMNAMAPTCNR2 | |
| SCHEMBL4966282 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1LMNAMAPTCNR2 | |
| SCHEMBL4966267 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1LMNAMAPTCNR2 | |
| SCHEMBL14563948 | 0.94 | CNR2 (0.46) | KDM4EALDH1A1LMNAMAPTCNR2 | |
| SCHEMBL4966095 | 0.82 | CNR2 (0.62) | CNR2CNR1KCNH2 | |
| SCHEMBL4965533 | 0.81 | CNR2 (0.64) | CNR2CNR1 | |
| SCHEMBL4967074 | 0.80 | KDM4E (0.47) | KDM4EALDH1A1LMNAMAPTCNR2 | |
| SCHEMBL4965882 | 0.80 | PAX8 (0.50) | ALDH1A1LMNAPKM | |
| SCHEMBL4967702 | 0.80 | CNR2 (0.58) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673369-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | AstraZeneca AB (SE) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005030761-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-04-07 | — | — | WO | disclosed |