Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 11/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16736623 | 0.90 | MAPT (0.62) | MAPTHSD17B10GABRG2GABRB3GABRA5 | |
| SCHEMBL7034135 | 0.86 | MAPT (0.57) | MAPTHSD17B10GABRG2GABRB3GABRA5 | |
| SCHEMBL29587146 | 0.82 | MAPT (0.56) | MAPTHSD17B10DDB1CRBNIKZF3 | |
| SCHEMBL8036351 | 0.80 | HSD17B10 (0.52) | HSD17B10CNR2CDK9FGFR1 | |
| SCHEMBL521597 | 0.77 | HSD17B10 (0.64) | MAPTHSD17B10FGFR1 | |
| SCHEMBL16034860 | 0.76 | CDK9 (0.48) | CNR1CNR2CDK9 | |
| SCHEMBL7035608 | 0.75 | NPSR1 (0.49) | MAPTHSD17B10CDK9PIK3CDGABRG2 | |
| SCHEMBL23902660 | 0.75 | CNR2 (0.49) | CNR1CNR2PIK3CD | |
| SCHEMBL30364834 | 0.75 | CNR2 (0.49) | CNR1CNR2PIK3CD | |
| SCHEMBL29052884 | 0.74 | F2 (0.49) | CDK9CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673369-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | AstraZeneca AB (SE) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005030761-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-04-07 | — | — | WO | disclosed |