Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.60 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | SPR | P35270 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 3/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL572238 | 1.00 | ALK (0.60) | ALKMETMAP3K7IRAK4BRD4 | |
| SCHEMBL571730 | 0.90 | SPR (0.51) | ALKMETMAP3K7IRAK4BRD4 | |
| SCHEMBL10270274 | 0.87 | ALK (0.78) | ALKMETMAP3K7IRAK4SPR | |
| SCHEMBL572240 | 0.87 | ALK (0.78) | ALKMETMAP3K7IRAK4SPR | |
| SCHEMBL572510 | 0.82 | SPR (0.59) | ALKMAP3K7IRAK4BRD4CREBBP | |
| SCHEMBL17208390 | 0.80 | ALK (0.67) | ALKMETMAP3K7IRAK4SPR | |
| SCHEMBL17210457 | 0.80 | ALK (0.66) | ALKMETMAP3K7IRAK4SPR | |
| SCHEMBL572515 | 0.78 | ALK (0.44) | ALKMETMAP3K7IRAK4BRD4 | |
| SCHEMBL572514 | 0.78 | ALK (0.44) | ALKMETMAP3K7IRAK4BRD4 | |
| SCHEMBL571731 | 0.77 | ALK (0.66) | ALKMETMAP3K7IRAK4SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611784-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | Amgen, Inc (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012018668-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC. (US) | 2012-02-09 | — | — | WO | disclosed |