Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 9/20 | 0.64 |
| ▸ | MME | P08473 | 2/20 | 0.64 |
| ▸ | ACE | P12821 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5723300 | 0.86 | ECE1 (0.84) | ECE1MMEACELMNAKAT6A | |
| SCHEMBL5723778 | 0.85 | MME (0.56) | ECE1MMEACEKAT6A | |
| SCHEMBL5724183 | 0.80 | ECE1 (0.54) | ECE1MMEACELMNAHPGD | |
| SCHEMBL5723060 | 0.79 | ECE1 (0.79) | ECE1MMEACELMNAEIF2AK3 | |
| SCHEMBL5723028 | 0.79 | MME (0.76) | ECE1MMEACEPOLBHCRTR2 | |
| SCHEMBL5723229 | 0.79 | ECE1 (0.69) | ECE1MMEACELMNAHPGD | |
| SCHEMBL5723089 | 0.78 | ECE1 (1.00) | ECE1MMEACELMNAKAT6A | |
| SCHEMBL5722920 | 0.78 | ECE1 (0.58) | ECE1MMEACELMNAHPGD | |
| SCHEMBL5723003 | 0.77 | ECE1 (0.69) | ECE1MMEACELMNAHPGD | |
| SCHEMBL5723097 | 0.77 | ECE1 (0.67) | ECE1MMEACELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317428-B1 | PYRROLIDINE-2-CARBOXYLIC ACID HYDRAZIDE DERIVATIVES FOR USE AS METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2006-04-19 | — | — | EP | disclosed |