Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.70 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.70 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.70 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.70 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.70 |
| ▸ | APP | P05067 | 7/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16353290 | 0.93 | AKR1C3 (0.78) | AKR1C3AKR1C2AKR1C1AKR1B10AKR1C4 | |
| SCHEMBL16897638 | 0.86 | AKR1C3 (0.65) | AKR1C3AKR1C2AKR1C1AKR1B10AKR1C4 | |
| SCHEMBL2794618 | 0.85 | AKR1C3 (0.57) | AKR1C3AKR1C2AKR1C1AKR1B10AKR1C4 | |
| SCHEMBL2853891 | 0.82 | AKR1C1 (0.53) | AKR1C3AKR1C2AKR1C1AKR1B10AKR1C4 | |
| SCHEMBL17713205 | 0.82 | APP (0.55) | AKR1C3AKR1C2AKR1C1AKR1B10AKR1C4 | |
| SCHEMBL2790932 | 0.81 | AKR1C3 (0.57) | AKR1C3AKR1C2AKR1C1AKR1B10AKR1C4 | |
| SCHEMBL17713173 | 0.80 | LMNA (0.57) | AKR1C3AKR1C2AKR1C1AKR1B10AKR1C4 | |
| SCHEMBL21874264 | 0.79 | LMNA (0.59) | AKR1C3AKR1C2AKR1C1AKR1B10AKR1C4 | |
| SCHEMBL2852643 | 0.79 | AKR1C1 (0.49) | AKR1C3AKR1C2AKR1C1AKR1B10AKR1C4 | |
| SCHEMBL10110060 | 0.78 | AKR1C1 (0.57) | AKR1C3AKR1C2AKR1C1AKR1B10AKR1C4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556347-A4 | GAMMA LACTAMS AS PROSTAGLANDIN AGONISTS AND USE THEREOF | APPLIED RESEARCH SYSTEMS (AN) | 2006-08-09 | — | — | EP | disclosed |
| EP-1556347-A2 | GAMMA LACTAMS AS PROSTAGLANDIN AGONISTS AND USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2005-07-27 | — | — | EP | disclosed |
| WO-2003103604-A2 | GAMMA LACTAMS AS PROSTAGLANDIN AGONISTS AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V (AN) | 2003-12-18 | — | — | WO | disclosed |