Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 4/20 | 0.70 |
| ▸ | MME | P08473 | 2/20 | 0.70 |
| ▸ | ACE | P12821 | 2/20 | 0.70 |
| ▸ | KAT6A | Q92794 | 5/20 | 0.55 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.47 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5723632 | 0.88 | ECE1 (0.71) | ECE1MMEACEKAT6AHCRTR1 | |
| Dimethylamine SCHEMBL5724587 | 0.86 | ECE1 (0.66) | ECE1MMEACEHCRTR1HCRTR2 | |
| SCHEMBL5723488 | 0.86 | ECE1 (0.66) | ECE1MMEACEHCRTR1HCRTR2 | |
| SCHEMBL5723097 | 0.85 | ECE1 (0.67) | ECE1MMEACEHCRTR1HCRTR2 | |
| SCHEMBL5722964 | 0.84 | ECE1 (0.64) | ECE1MMEACEHCRTR1HCRTR2 | |
| SCHEMBL5722970 | 0.84 | ECE1 (0.64) | ECE1MMEACEHCRTR1HCRTR2 | |
| SCHEMBL5723300 | 0.83 | ECE1 (0.84) | ECE1MMEACEKAT6AHCRTR1 | |
| SCHEMBL5723089 | 0.82 | ECE1 (1.00) | ECE1MMEACEKAT6AHCRTR1 | |
| SCHEMBL5723518 | 0.82 | ECE1 (0.56) | ECE1MMEACEHCRTR1HCRTR2 | |
| SCHEMBL5723246 | 0.82 | ECE1 (0.63) | ECE1MMEACEHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317428-B1 | PYRROLIDINE-2-CARBOXYLIC ACID HYDRAZIDE DERIVATIVES FOR USE AS METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2006-04-19 | — | — | EP | disclosed |