SCHEMBL5723804

SCHEMBL5723804

C=CC(=O)N(CCNC(=O)O)C(c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1)C(C)C

nearest known ligand 0.61

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 6/20 0.61
MAP1LC3B Q9GZQ8 3/20 0.61
CYP3A4 P08684 2/20 0.61
CYP2C19 P33261 1/20 0.61
KCNH2 Q12809 1/20 0.61
PDE6D O43924 3/20 0.49
NAMPT P43490 7/20 0.43
APP P05067 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5723915 1.00 KIF11 (0.61) KIF11MAP1LC3BCYP3A4CYP2C19KCNH2
SCHEMBL5523041 0.90 KIF11 (0.54) KIF11MAP1LC3BCYP3A4CYP2C19KCNH2
SCHEMBL5524193 0.90 KIF11 (0.54) KIF11MAP1LC3BCYP3A4CYP2C19KCNH2
SCHEMBL5520334 0.90 KIF11 (0.68) KIF11MAP1LC3BCYP3A4CYP2C19KCNH2
SCHEMBL5522023 0.90 KIF11 (0.68) KIF11MAP1LC3BCYP3A4CYP2C19KCNH2
SCHEMBL5521482 0.86 KIF11 (0.59) KIF11MAP1LC3BCYP3A4CYP2C19KCNH2
SCHEMBL5533059 0.83 KIF11 (0.53) KIF11MAP1LC3BCYP3A4CYP2C19KCNH2
SCHEMBL16096544 0.82 KIF11 (0.83) KIF11MAP1LC3BCYP3A4CYP2C19KCNH2
SCHEMBL6353088 0.82 KIF11 (0.77) KIF11MAP1LC3BCYP3A4CYP2C19KCNH2
SCHEMBL5724300 0.81 KIF11 (0.55) KIF11MAP1LC3BCYP3A4CYP2C19KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1581520-A4 COMPOUNDS, COMPOSITIONS AND METHODS SMITHKLINE BEECHAM CORP (US) 2006-08-23 EP disclosed
EP-1581520-A1 COMPOUNDS, COMPOSITIONS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2005-10-05 EP disclosed
WO-2004055008-A1 COMPOUNDS, COMPOSITIONS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2004-07-01 WO disclosed