Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL5724927

CCCC(c1ccccc1)c1ccccc1.N

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 8/20 0.54
HTR2A P28223 8/20 0.54
SIGMAR1 Q99720 1/20 0.52
AOC3 Q16853 2/20 0.48
CYP3A4 P08684 2/20 0.48
LMNA P02545 2/20 0.48
HTR1A P08908 2/20 0.48
ADORA3 P0DMS8 2/20 0.48
SLC6A2 P23975 2/20 0.48
SLC6A4 P31645 2/20 0.48
ADRA1A P35348 2/20 0.48
OPRM1 P35372 2/20 0.48
DRD3 P35462 2/20 0.48
SLC6A3 Q01959 2/20 0.48
KCNH2 Q12809 2/20 0.48
CHRM2 P08172 1/20 0.48
ADRA2A P08913 1/20 0.48
CHRM1 P11229 1/20 0.48
SMPD1 P17405 1/20 0.48
DRD1 P21728 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL107889 0.97 HRH1 (0.56) HRH1HTR2ASIGMAR1AOC3CYP3A4
Hydrochloric Acid SCHEMBL6521685 0.95 HRH1 (0.54) HRH1HTR2ASIGMAR1AOC3CYP3A4
SCHEMBL28229621 0.95 HRH1 (0.54) HRH1HTR2ASIGMAR1AOC3CYP3A4
Hydrogen Peroxide SCHEMBL27864054 0.95 HRH1 (0.54) HRH1HTR2ASIGMAR1AOC3CYP3A4
Ethylene SCHEMBL28169737 0.92 HRH1 (0.52) HRH1HTR2ASIGMAR1AOC3CYP3A4
Diethylamine SCHEMBL11102663 0.86 HRH1 (0.52) HRH1HTR2ASIGMAR1AOC3CYP3A4
SCHEMBL6546820 0.86 CNR1 (0.51) HRH1HTR2ASIGMAR1AOC3CYP3A4
SCHEMBL29173261 0.84 SLC6A2 (0.57) HRH1HTR2ASIGMAR1LMNASLC6A2
SCHEMBL8320391 0.84 HTR2A (0.45) HRH1HTR2ASIGMAR1AOC3CYP3A4
SCHEMBL7918988 0.84 HRH1 (0.45) HRH1HTR2ASIGMAR1AOC3CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0812318-B1 4-AMINOTETRAHYDROBENZISOXAZOLE OR -ISOTHIAZOLE COMPOUNDS LUNDBECK & CO AS H (DK) 2006-02-08 EP disclosed
US-6174909-B1 FOR TREATING ANALGESIA, PSYCHOSIS, CONVULSIONS, EPILEPSY, ANXIETY, MUSCULAR AND MOVEMENT DISORDERS, SPASTIC DISORDERS OR SYMPTOMS OF HUNTINGTON'S OR PARKINSONS DISEASE H. LUNDBECK A/S (DK) 2001-01-16 US disclosed
US-5998613-A PSYCHOLOGICAL DISORDERS; ANALGESICS; ANTICONVULSANTS H. LUNDBECK A/S (DK) 1999-12-07 US disclosed
EP-0812318-A1 4-AMINOTETRAHYDROBENZISOXAZOLE OR -ISOTHIAZOLE COMPOUNDS H. LUNDBECK A/S (DK) 1997-12-17 EP disclosed
WO-1996026929-A1 4-AMINOTETRAHYDROBENZISOXAZOLE OR -ISOTHIAZOLE COMPOUNDS H. LUNDBECK A/S (DK) 1996-09-06 WO disclosed
US-5514672-A Use of retinoids and compositions containing same for hair growth BAZZANO GAIL S (US) 1996-05-07 US disclosed