Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 5/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4477734 | 0.84 | RXFP1 (0.56) | CDK8RXFP1CDK7CDK6MAPK14 | |
| SCHEMBL9100139 | 0.81 | KDR (0.60) | CDK8CDK7CDK6MAPK14KDR | |
| SCHEMBL9101092 | 0.81 | KDR (0.49) | CDK8CDK7CDK6MAPK14KDR | |
| SCHEMBL9102775 | 0.79 | SMN1; SMN2 (0.49) | MAPTHTTRAB9AFAAH | |
| SCHEMBL16907464 | 0.79 | MAPT (0.66) | RXFP1MAPTMEN1HTTRAB9A | |
| SCHEMBL9106921 | 0.78 | HPGD (0.48) | MAPK14KDRTNNI3KBRAFMAPT | |
| SCHEMBL8148883 | 0.75 | KCNK3 (0.69) | RXFP1MAPK14KDRTNNI3KBRAF | |
| SCHEMBL28209722 | 0.74 | KMT2A (0.62) | MAPTMEN1HTTRAB9AKMT2A | |
| SCHEMBL5725295 | 0.74 | ICMT (0.46) | MAPTRAB9A | |
| SCHEMBL23447712 | 0.71 | MAPT (0.63) | RXFP1MAPTMEN1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685125-B1 | Pyrrole derivatives useful for the treatment of proliferative diseases | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | disclosed |
| EP-1685125-A1 | PYRROL DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005049603-A1 | PYRROL DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-06-02 | — | — | WO | disclosed |