Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 9/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214451 | 0.90 | CSNK1D (0.51) | MAPK8MAPK9MAPK10CSNK1DCDK4 | |
| SCHEMBL5214934 | 0.88 | EIF2AK2 (0.51) | MAPK8MAPK9MAPK10CDK4GSK3B | |
| SCHEMBL5726203 | 0.86 | EIF2AK2 (0.41) | MAPK8MAPK9MAPK10CSNK1DCDK4 | |
| SCHEMBL5726088 | 0.84 | EIF2AK2 (0.42) | MAPK8MAPK9MAPK10CSNK1DCDK4 | |
| SCHEMBL5724993 | 0.83 | CSNK1D (0.48) | MAPK8MAPK9MAPK10CSNK1DCDK4 | |
| SCHEMBL6182652 | 0.82 | GSK3B (0.58) | GSK3B | |
| SCHEMBL5725747 | 0.81 | EIF2AK2 (0.48) | MAPK8MAPK9MAPK10GSK3B | |
| SCHEMBL6105772 | 0.81 | CDK4 (0.44) | MAPK8MAPK9MAPK10CSNK1DCDK4 | |
| SCHEMBL5725886 | 0.81 | CSNK1D (0.46) | MAPK8MAPK9MAPK10CSNK1DCDK4 | |
| SCHEMBL5463503 | 0.80 | MAPK10 (0.43) | MAPK8MAPK9MAPK10CSNK1DCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377575-B1 | ANTIVIRAL PYRAZOLOPYRIDINE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2006-07-05 | — | — | EP | claimed |
| EP-1377575-B1 | ANTIVIRAL PYRAZOLOPYRIDINE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2006-07-05 | — | — | EP | disclosed |