Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726424 | 0.89 | MAPT (0.41) | ALDH1A1MAPK1HSD17B10MAPTTSHR | |
| SCHEMBL5726595 | 0.85 | ALDH1A1 (0.42) | ABCB1ALDH1A1MAPK1HSD17B10MAPT | |
| SCHEMBL5726249 | 0.83 | ABCB1 (0.47) | ABCB1ALDH1A1MAPK1HSD17B10MAPT | |
| SCHEMBL5726364 | 0.83 | ABCB1 (0.60) | ABCB1ALDH1A1MAPK1HSD17B10MAPT | |
| SCHEMBL5725943 | 0.82 | ABCB1 (0.48) | ABCB1ALDH1A1MAPK1HSD17B10MAPT | |
| SCHEMBL5726497 | 0.82 | ABCB1 (0.48) | ABCB1ALDH1A1MAPK1HSD17B10MAPT | |
| SCHEMBL5727637 | 0.82 | ALDH1A1 (0.40) | ABCB1ALDH1A1MAPK1HSD17B10MAPT | |
| SCHEMBL5726257 | 0.80 | ALDH1A1 (0.48) | ABCB1ALDH1A1MAPK1HSD17B10MAPT | |
| SCHEMBL5726381 | 0.80 | ALDH1A1 (0.48) | ABCB1ALDH1A1MAPK1HSD17B10MAPT | |
| SCHEMBL5726637 | 0.80 | ALDH1A1 (0.48) | ABCB1ALDH1A1MAPK1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7138404-B2 | 4-aminopyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-11-21 | — | — | US | claimed |
| EP-1395568-B1 | 4-AMINOPYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-11-02 | — | — | EP | claimed |
| EP-1395568-A1 | 4-AMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-03-10 | — | — | EP | claimed |
| US-20030022907-A1 | 4-aminopyrimidine derivatives | HOFFMANN-LA ROCHE INC. | 2003-01-30 | — | — | US | claimed |
| WO-2002094795-A1 | 4-AMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-11-28 | — | — | WO | claimed |
| US-7138404-B2 | 4-aminopyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-11-21 | — | — | US | disclosed |
| EP-1395568-B1 | 4-AMINOPYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-11-02 | — | — | EP | disclosed |
| EP-1395568-A1 | 4-AMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-03-10 | — | — | EP | disclosed |
| US-20030022907-A1 | 4-aminopyrimidine derivatives | HOFFMANN-LA ROCHE INC. | 2003-01-30 | — | — | US | disclosed |
| WO-2002094795-A1 | 4-AMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030022907-A1 | 4-aminopyrimidine derivatives | GRM5, GRIK5, GRM1 | ABCB1 510/4885ALDH1A1 786/4885MAPK1 1232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.