Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 18/20 | 0.72 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.72 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.72 |
| ▸ | ESRRG | P62508 | 12/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.52 |
| ▸ | ESRRB | O95718 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726861 | 1.00 | ESR1 (0.72) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL5727007 | 0.96 | ESR1 (0.66) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL7109996 | 0.96 | ESR1 (0.66) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL7109988 | 0.96 | ESR1 (0.66) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL7519055 | 0.96 | ESR1 (0.66) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL6373219 | 0.95 | ESR1 (0.65) | ESR1CYP19A1ESR2ESRRGLMNA | |
| Hydrochloric Acid SCHEMBL7205293 | 0.95 | ESR1 (0.65) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL6373225 | 0.95 | ESR1 (0.65) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL6374444 | 0.95 | ESR1 (0.65) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL8362771 | 0.94 | ESR1 (0.63) | ESR1CYP19A1ESR2ESRRGLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1705169-A2 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators | Hormos Medical Ltd. (FI) | 2006-09-27 | — | — | EP | disclosed |
| EP-1235776-B1 | TRIPHENYLALKENE DERIVATIVES AND THEIR USE AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | HORMOS MEDICAL CORP (FI) | 2006-02-08 | — | — | EP | disclosed |
| US-6875775-B2 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators | HORMOS MEDICAL OY LTD (FI) | 2005-04-05 | — | — | US | disclosed |
| US-20030225130-A1 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators | HORMOS MEDICAL OY LTD. | 2003-12-04 | — | — | US | disclosed |
| US-6576645-B1 | Such as 3-(4-chloro-1-(4-(2-(2-hydroxyethoxy)ethoxy)phenyl)--2-phenylbut-1 -enyl)phenol; producing tissue specific estro-genic and/or antiestrogenic effect | HORMOS MEDICAL OY LTD (FI) | 2003-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225130-A1 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators | ESR2, ESR1, GPER1 | ESR1 2/4885CYP19A1 11/4885ESR2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.