SCHEMBL5727147

SCHEMBL5727147

O=C(NCC1CN(c2ccc(N3CCNCC3)c(F)c2)C(=O)O1)C(F)F

nearest known ligand 0.70

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 11/20 0.70
MAOB P27338 7/20 0.64
MAOA P21397 4/20 0.64
PTGS1 P23219 2/20 0.64
SDHA P31040 2/20 0.64
LMNA P02545 1/20 0.64
CALML3 P27482 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5727141 1.00 F10 (0.70) F10MAOBMAOAPTGS1SDHA
SCHEMBL6730699 0.93 F10 (0.60) F10MAOBMAOAPTGS1SDHA
SCHEMBL5133835 0.92 F10 (0.71) F10MAOBMAOAPTGS1SDHA
SCHEMBL5727001 0.92 F10 (0.71) F10MAOBMAOAPTGS1SDHA
SCHEMBL13368055 0.90 MAOB (0.64) F10MAOBMAOAPTGS1SDHA
SCHEMBL13428565 0.90 MAOB (0.58) F10MAOBMAOAPTGS1SDHA
SCHEMBL7262409 0.90 F10 (0.67) F10MAOBMAOAPTGS1SDHA
SCHEMBL7256929 0.90 F10 (0.67) F10MAOBMAOAPTGS1SDHA
SCHEMBL5727254 0.90 F10 (0.69) F10MAOBMAOAPTGS1SDHA
SCHEMBL7256769 0.90 F10 (0.67) F10MAOBMAOAPTGS1SDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060293307-A1 Oxazolidinone derivatives as antimicrobials RANBAXY LABORATORIES LIMITED (IN) 2006-12-28 US disclosed
EP-1542696-A4 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS RANBAXY LAB LTD (IN) 2006-08-02 EP disclosed
EP-1542696-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS RANBAXY LABORATORIES, LTD. (IN) 2005-06-22 EP disclosed
US-20040242591-A1 Oxazolidinone derivatives as pontential antimicrobials RANBAXY LABORATORIES LIMITED (IN) 2004-12-02 US disclosed
EP-1409464-A1 OXAZOLIDINONE DERIVATIVES AS POTENTIAL ANTIMICROBIALS RANBAXY LABORATORIES, LTD. (IN) 2004-04-21 EP disclosed
WO-2004014392-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS RANBAXY LABORATORIES LIMITED (IN) 2004-02-19 WO disclosed
WO-2003008389-A1 OXAZOLIDINONE DERIVATIVES AS POTENTIAL ANTIMICROBIALS RANBAXY LABORATORIES LIMITED (IN) 2003-01-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040242591-A1 Oxazolidinone derivatives as pontential antimicrobials PDK4, OXA1L, PPARD F10 2578/4885MAOB 1961/4885MAOA 1955/4885
US-20060293307-A1 Oxazolidinone derivatives as antimicrobials OXA1L, PDK4, SDHA F10 1403/4885MAOB 1976/4885MAOA 1568/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.