⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2985550 | 1.00 | — | — | |
| SCHEMBL17162480 | 1.00 | — | — | |
| SCHEMBL2909263 | 1.00 | — | — | |
| SCHEMBL2913695 | 1.00 | — | — | |
| SCHEMBL2911929 | 1.00 | — | — | |
| SCHEMBL17162469 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL2918760 | 0.99 | — | — | |
| SCHEMBL3043623 | 0.90 | — | — | |
| SCHEMBL3792793 | 0.90 | — | — | |
| SCHEMBL3038336 | 0.87 | PER2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11642339-B2 | Methods of treating symptoms of gastroparesis using velusetrag | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-05-09 | — | — | US | claimed |
| EP-1735304-A1 | QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | Theravance, Inc. (US) | 2006-12-27 | — | — | EP | claimed |
| WO-2005100350-A1 | QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE, INC. (US) | 2005-10-27 | — | — | WO | claimed |
| US-20150291580-A1 | QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-10-15 | — | — | US | disclosed |
| US-8575192-B2 | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists | THERAVANCE, INC. (US) | 2013-11-05 | — | — | US | disclosed |