Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ACACB | O00763 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726654 | 0.86 | ACACB (0.67) | KMT2AMEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL23928126 | 0.84 | TAAR1 (0.55) | KMT2AMEN1TAAR1RAB9ANPC1 | |
| SCHEMBL17935564 | 0.84 | NPC1 (0.68) | KMT2AMEN1TAAR1RAB9ANPC1 | |
| SCHEMBL23928192 | 0.84 | KMT2A (0.54) | KMT2AMEN1TAAR1RAB9ANPC1 | |
| SCHEMBL1309567 | 0.83 | ALDH1A1 (0.55) | KMT2AMEN1TAAR1RAB9ANPC1 | |
| SCHEMBL23928140 | 0.83 | KMT2A (0.59) | KMT2AMEN1TAAR1RAB9ANPC1 | |
| SCHEMBL4519919 | 0.81 | MAPT (0.67) | KMT2ARAB9ANPC1SMN1; SMN2ACACB | |
| SCHEMBL23928111 | 0.81 | HRH3 (0.62) | KMT2AMEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL15822904 | 0.81 | KMT2A (0.50) | KMT2AMEN1TAAR1RAB9ANPC1 | |
| SCHEMBL9439608 | 0.81 | KMT2A (0.53) | KMT2AMEN1TAAR1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1502590-B1 | Heterocyclic oxime derivatives, process for their preparation and use thereof in the treatment of type II diabetes | SERVIER LAB (FR) | 2006-12-20 | — | — | EP | disclosed |
| EP-1502590-A1 | Heterocyclic oxime derivatives, process for their preparation and use thereof in the treatment of type II diabetes | Les Laboratoires Servier (FR) | 2005-02-02 | — | — | EP | disclosed |